Two sample MR report

Telomere_length against IDP T1 SIENAX CSF unnormalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0482886	0.1147724	0.6782241
Weighted median	23	0.0488468	0.0565259	0.3875064
Inverse variance weighted	23	-0.0160504	0.0439253	0.7148115
Simple mode	23	0.0544296	0.0931133	0.5647958
Weighted mode	23	0.0396055	0.0617943	0.5281926

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.11221	21	0.1113336
Inverse variance weighted	29.24130	22	0.1380995

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019797	0.0064872	0.7632456

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008914	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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