Two sample MR report

Telomere_length against IDP T1 SIENAX CSF normalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0453257	0.1148807	0.6971564
Weighted median	23	0.0431786	0.0574005	0.4519102
Inverse variance weighted	23	-0.0161433	0.0439490	0.7133817
Simple mode	23	0.0551884	0.0909398	0.5501513
Weighted mode	23	0.0441254	0.0618047	0.4827655

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.16714	21	0.1100462
Inverse variance weighted	29.27293	22	0.1372323

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001792	0.0064933	0.785263

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008924	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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