Two sample MR report

Telomere_length against IDP T1 FIRST right thalamus volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1278738	0.1332144	0.3480231
Weighted median	23	-0.1040478	0.0568849	0.0673853
Inverse variance weighted	23	-0.0246300	0.0517232	0.6339393
Simple mode	23	-0.1061939	0.0919660	0.2605986
Weighted mode	23	-0.1238082	0.0584255	0.0456085

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.20788	21	0.0092689
Inverse variance weighted	40.53156	22	0.0093646

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00634	0.0075297	0.4092735

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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