Two sample MR report

Telomere_length against IDP T1 FIRST right putamen volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0374552	0.1360589	0.7857864
Weighted median	23	-0.0520874	0.0619954	0.4008063
Inverse variance weighted	23	-0.0249470	0.0522640	0.6331294
Simple mode	23	-0.1820088	0.1525560	0.2455534
Weighted mode	23	-0.1092922	0.0960790	0.2675569

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.89997	21	0.0057690
Inverse variance weighted	41.38353	22	0.0074164

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003832	0.0076905	0.6234652

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012669	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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