Two sample MR report

Telomere_length against IDP T1 FIRST right pallidum volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1232593	0.1047386	0.2524313
Weighted median	23	-0.0678724	0.0556571	0.2226645
Inverse variance weighted	23	-0.0346111	0.0424740	0.4151419
Simple mode	23	-0.0330935	0.1083640	0.7629386
Weighted mode	23	-0.0330935	0.0680975	0.6317924

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.23627	21	0.2817517
Inverse variance weighted	27.33109	22	0.1989202

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0096945	0.0059201	0.1164144

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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