Two sample MR report

Telomere_length against IDP T1 FIRST right hippocampus volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1092287	0.1490780	0.4718442
Weighted median	23	-0.0268197	0.0663170	0.6859060
Inverse variance weighted	23	0.0301457	0.0583115	0.6051723
Simple mode	23	0.2935447	0.1693259	0.0969821
Weighted mode	23	-0.1389608	0.0986235	0.1728128

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.10374	21	0.0004855
Inverse variance weighted	51.51607	22	0.0003645

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085588	0.0084264	0.3213268

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00158	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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