Two sample MR report

Telomere_length against IDP T1 FIRST right caudate volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0264302	0.1287435	0.8393200
Weighted median	23	-0.0084004	0.0615375	0.8914191
Inverse variance weighted	23	-0.0545829	0.0492299	0.2675452
Simple mode	23	0.0636083	0.1262494	0.6193887
Weighted mode	23	-0.0590259	0.0935990	0.5347827

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.62011	21	0.0186047
Inverse variance weighted	36.71853	22	0.0253936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017288	0.007277	0.8145158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011748	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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