Two sample MR report

Telomere_length against IDP T1 FIRST right amygdala volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1266626	0.1104494	0.2643662
Weighted median	23	0.0567462	0.0616993	0.3577186
Inverse variance weighted	23	-0.0197867	0.0442129	0.6544904
Simple mode	23	0.0546696	0.1085709	0.6195906
Weighted mode	23	0.0691925	0.0817749	0.4065876

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.95190	21	0.1724509
Inverse variance weighted	29.61519	22	0.1281210

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089932	0.006243	0.1644597

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009056	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis