Two sample MR report

Telomere_length against IDP T1 FIRST right accumbens volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0479304	0.1125884	0.6746475
Weighted median	23	0.0071414	0.0614995	0.9075565
Inverse variance weighted	23	-0.0325405	0.0430180	0.4493859
Simple mode	23	0.0971760	0.1318890	0.4690281
Weighted mode	23	0.0594198	0.1096448	0.5933140

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.00733	21	0.1399437
Inverse variance weighted	28.03674	22	0.1744668

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009451	0.006364	0.88336

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008717	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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