Two sample MR report

Telomere_length against IDP T1 FIRST left thalamus volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1201465	0.1255109	0.3493279
Weighted median	23	-0.1275655	0.0535201	0.0171486
Inverse variance weighted	23	-0.0485661	0.0483662	0.3153145
Simple mode	23	-0.1260503	0.0750419	0.1071567
Weighted mode	23	-0.1345940	0.0560562	0.0252389

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.80449	21	0.0296615
Inverse variance weighted	35.44076	22	0.0348261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043956	0.0070943	0.5421841

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011231	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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