Two sample MR report

Telomere_length against IDP T1 FIRST left putamen volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0472103	0.1423771	0.7434882
Weighted median	23	-0.0108687	0.0625509	0.8620563
Inverse variance weighted	23	-0.0241342	0.0547525	0.6593676
Simple mode	23	0.1192121	0.1406920	0.4059368
Weighted mode	23	0.0636863	0.0979820	0.5224351

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.78666	21	0.0018471
Inverse variance weighted	45.41873	22	0.0023475

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043811	0.0080476	0.5918991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013884	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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