Two sample MR report

Telomere_length against IDP T1 FIRST left pallidum volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1199802	0.1096596	0.2862958
Weighted median	23	-0.0153489	0.0577154	0.7902849
Inverse variance weighted	23	0.0037039	0.0431789	0.9316405
Simple mode	23	-0.0724980	0.1123464	0.5254012
Weighted mode	23	-0.0641392	0.0720292	0.3828536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.56723	21	0.1856408
Inverse variance weighted	28.24610	22	0.1676681

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071403	0.0061983	0.2622763

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008562	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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