Two sample MR report

Telomere_length against IDP T1 FIRST left hippocampus volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0226094	0.0974952	0.8188583
Weighted median	23	-0.0320468	0.0537704	0.5511793
Inverse variance weighted	23	-0.0451403	0.0381073	0.2361924
Simple mode	23	-0.0378502	0.0826304	0.6513972
Weighted mode	23	-0.0458479	0.0643955	0.4839639

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.26291	21	0.6323115
Inverse variance weighted	18.32594	22	0.6864978

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013836	0.0055107	0.8041998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005978	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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