Two sample MR report

Telomere_length against IDP T1 FIRST left caudate volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0301883	0.1395745	0.8308505
Weighted median	23	0.0224581	0.0632036	0.7223425
Inverse variance weighted	23	-0.0414731	0.0533095	0.4365884
Simple mode	23	0.1175486	0.1570880	0.4622057
Weighted mode	23	-0.1521307	0.0995604	0.1407576

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.04063	21	0.0031061
Inverse variance weighted	43.05645	22	0.0046442

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000693	0.0078892	0.930837

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013406	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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