Two sample MR report

Telomere_length against IDP T1 FIRST left amygdala volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0221458	0.1083707	0.8400456
Weighted median	23	-0.0458412	0.0596191	0.4419520
Inverse variance weighted	23	-0.0349787	0.0417063	0.4016429
Simple mode	23	-0.0020176	0.1159314	0.9862716
Weighted mode	23	-0.0124507	0.0881641	0.8889800

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.94707	21	0.2084744
Inverse variance weighted	26.35229	22	0.2368642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035079	0.0061255	0.5729433

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008241	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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