Two sample MR report

Telomere_length against IDP T1 FIRST left accumbens volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0004386	0.0974944	0.9964530
Weighted median	23	-0.1065439	0.0549815	0.0526458
Inverse variance weighted	23	-0.0471728	0.0381070	0.2157521
Simple mode	23	-0.1403006	0.1110725	0.2197609
Weighted mode	23	-0.1236869	0.0752366	0.1143979

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.10862	21	0.6421204
Inverse variance weighted	18.39011	22	0.6826244

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029237	0.0055107	0.6012924

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006037	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8