Two sample MR report

Telomere_length against IDP T1 FIRST brain stem+4th ventricle volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0809963	0.1599013	0.6177555
Weighted median	23	-0.1237310	0.0566246	0.0288807
Inverse variance weighted	23	-0.0812646	0.0610620	0.1832371
Simple mode	23	-0.3449899	0.1120336	0.0054834
Weighted mode	23	-0.1382803	0.0559764	0.0217274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.49001	21	4.27e-05
Inverse variance weighted	56.49002	22	7.27e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-1.65e-05	0.0090381	0.9985624

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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