Two sample MR report

Telomere_length against IDP T1 FAST ROIs brain stem

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0288314	0.1214194	0.8146069
Weighted median	23	-0.0361456	0.0576948	0.5309891
Inverse variance weighted	23	-0.0124762	0.0465173	0.7885414
Simple mode	23	-0.0946099	0.0999378	0.3540809
Weighted mode	23	-0.0761981	0.0726060	0.3053531

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.57860	21	0.0511038
Inverse variance weighted	32.79053	22	0.0648818

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025366	0.006863	0.7153759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009969	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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