Two sample MR report

Telomere_length against IDP T1 FAST ROIs V cerebellum crus II

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0255648	0.1274833	0.8429918
Weighted median	23	-0.0020510	0.0531370	0.9692113
Inverse variance weighted	23	-0.0183390	0.0488440	0.7073183
Simple mode	23	0.0163034	0.0829391	0.8459683
Weighted mode	23	0.0022694	0.0569206	0.9685564

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.91311	21	0.0223616
Inverse variance weighted	36.15252	22	0.0292427

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002696	0.0072057	0.7120426

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011025	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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