Two sample MR report

Telomere_length against IDP T1 FAST ROIs V cerebellum crus I

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2114049	0.1176335	0.0867096
Weighted median	23	-0.0506557	0.0622532	0.4158143
Inverse variance weighted	23	-0.0105407	0.0484621	0.8278153
Simple mode	23	-0.0997437	0.1238955	0.4293987
Weighted mode	23	-0.0752046	0.0893709	0.4091285

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.57894	21	0.0809568
Inverse variance weighted	35.59017	22	0.0335804

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0123348	0.0066491	0.0776735

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010808	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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