Two sample MR report

Telomere_length against IDP T1 FAST ROIs V cerebellum X

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1231156	0.1188751	0.3121351
Weighted median	23	-0.1122751	0.0586569	0.0556076
Inverse variance weighted	23	-0.0553041	0.0458082	0.2273186
Simple mode	23	-0.1132747	0.1001745	0.2703273
Weighted mode	23	-0.1092468	0.0782040	0.1763625

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.22748	21	0.0699545
Inverse variance weighted	31.79862	22	0.0808948

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041642	0.0067192	0.5420936

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010274	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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