Two sample MR report

Telomere_length against IDP T1 FAST ROIs V cerebellum VIIIb

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1640912	0.1320844	0.2278132
Weighted median	23	-0.0755967	0.0545496	0.1657974
Inverse variance weighted	23	-0.0553709	0.0513905	0.2812774
Simple mode	23	-0.1021723	0.0872998	0.2543782
Weighted mode	23	-0.0738914	0.0557766	0.1988429

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.55256	21	0.0110947
Inverse variance weighted	40.02064	22	0.0107518

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066763	0.0074658	0.3813242

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012766	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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