Two sample MR report

Telomere_length against IDP T1 FAST ROIs V cerebellum VIIIa

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0082419	0.1185655	0.9452383
Weighted median	23	-0.0005819	0.0531291	0.9912613
Inverse variance weighted	23	-0.0534677	0.0454612	0.2395485
Simple mode	23	-0.0308246	0.0856191	0.7222653
Weighted mode	23	-0.0129420	0.0637432	0.8409751

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.06423	21	0.0725956
Inverse variance weighted	31.31827	22	0.0897845

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027772	0.0067017	0.682779

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010086	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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