Two sample MR report

Telomere_length against IDP T1 FAST ROIs V cerebellum IX

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0611332	0.1373480	0.6608036
Weighted median	23	0.0163591	0.0540496	0.7621432
Inverse variance weighted	23	-0.0443860	0.0533117	0.4050841
Simple mode	23	-0.0323082	0.0998826	0.7494000
Weighted mode	23	0.0158548	0.0576966	0.7860366

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.68603	21	0.0046069
Inverse variance weighted	43.06892	22	0.0046278

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064797	0.0077633	0.4133057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013462	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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