Two sample MR report

Telomere_length against IDP T1 FAST ROIs R ventral striatum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0435824	0.1201898	0.7205177
Weighted median	23	-0.0251650	0.0555720	0.6506665
Inverse variance weighted	23	-0.0558696	0.0459101	0.2236287
Simple mode	23	0.0105009	0.1014752	0.9185179
Weighted mode	23	-0.0475316	0.0630175	0.4586908

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.92132	21	0.0596326
Inverse variance weighted	31.94007	22	0.0784234

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007545	0.0067935	0.9126179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001033	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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