Two sample MR report

Telomere_length against IDP T1 FAST ROIs R thalamus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0175464	0.1311789	0.8948664
Weighted median	23	0.0080713	0.0571664	0.8877207
Inverse variance weighted	23	-0.0054784	0.0501050	0.9129349
Simple mode	23	0.0410821	0.0887803	0.6480958
Weighted mode	23	0.0161588	0.0615206	0.7952596

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.02548	21	0.0128003
Inverse variance weighted	38.04357	22	0.0181167

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007411	0.0074147	0.921334

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011534	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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