Two sample MR report

Telomere_length against IDP T1 FAST ROIs R temporal pole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1209651	0.1333717	0.3747092
Weighted median	23	0.1460192	0.0626491	0.0197668
Inverse variance weighted	23	0.0708236	0.0538097	0.1881118
Simple mode	23	0.1682946	0.1186993	0.1702517
Weighted mode	23	0.1372781	0.1167724	0.2523190

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.31002	21	0.0090110
Inverse variance weighted	43.87883	22	0.0036724

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0117775	0.0075387	0.1331665

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014342	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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