Two sample MR report

Telomere_length against IDP T1 FAST ROIs R supramarg gyrus post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0141921	0.1247874	0.9105321
Weighted median	23	-0.0011440	0.0628128	0.9854693
Inverse variance weighted	23	-0.0175418	0.0477389	0.7132812
Simple mode	23	-0.1274335	0.1193066	0.2970483
Weighted mode	23	-0.0057897	0.0729577	0.9374665

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.41034	21	0.0327364
Inverse variance weighted	34.53542	22	0.0432966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019487	0.0070534	0.7850331

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010529	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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