Two sample MR report

Telomere_length against IDP T1 FAST ROIs R supramarg gyrus ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0925146	0.1154911	0.4320710
Weighted median	23	-0.0223892	0.0564018	0.6913973
Inverse variance weighted	23	-0.0315464	0.0444466	0.4778527
Simple mode	23	0.0391865	0.0998272	0.6984345
Weighted mode	23	-0.0128390	0.0602215	0.8331369

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.47407	21	0.1030772
Inverse variance weighted	29.93573	22	0.1200348

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037439	0.0065279	0.5723798

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009279	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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