Two sample MR report

Telomere_length against IDP T1 FAST ROIs R sup parietal lobule

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1040560	0.1010710	0.3149415
Weighted median	23	-0.0466129	0.0599337	0.4367214
Inverse variance weighted	23	-0.0406654	0.0390203	0.2973375
Simple mode	23	0.1711087	0.1129825	0.1441424
Weighted mode	23	-0.0634020	0.0775227	0.4222118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.57345	21	0.3671356
Inverse variance weighted	23.07253	22	0.3976435

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038927	0.0057129	0.5030686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007337	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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