Two sample MR report

Telomere_length against IDP T1 FAST ROIs R sup front gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1116084	0.1186667	0.3576448
Weighted median	23	-0.0468265	0.0566374	0.4083633
Inverse variance weighted	23	0.0019068	0.0464662	0.9672665
Simple mode	23	-0.0948133	0.0975114	0.3414559
Weighted mode	23	-0.0398953	0.0691985	0.5701064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.11770	21	0.0717213
Inverse variance weighted	32.71813	22	0.0659504

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069707	0.0067074	0.310502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009915	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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