Two sample MR report

Telomere_length against IDP T1 FAST ROIs R putamen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1199275	0.1211395	0.3334472
Weighted median	23	-0.1796384	0.0601545	0.0028239
Inverse variance weighted	23	-0.1091683	0.0462695	0.0183044
Simple mode	23	-0.2350604	0.1264234	0.0764101
Weighted mode	23	-0.2318779	0.0942614	0.0222231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.42892	21	0.0529458
Inverse variance weighted	32.44329	22	0.0701462

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006607	0.0068473	0.9240446

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012318	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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