Two sample MR report

Telomere_length against IDP T1 FAST ROIs R precentral gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1036165	0.0974845	0.2998970
Weighted median	23	-0.0267346	0.0556915	0.6311929
Inverse variance weighted	23	-0.0414652	0.0381026	0.2764837
Simple mode	23	0.0370982	0.0926371	0.6926744
Weighted mode	23	0.0072545	0.0718513	0.9204928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.72955	21	0.6660485
Inverse variance weighted	18.20932	22	0.6935082

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038166	0.0055102	0.4961182

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005877	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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