Two sample MR report

Telomere_length against IDP T1 FAST ROIs R postcent gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2033550	0.0974839	0.0493582
Weighted median	23	-0.0145017	0.0565505	0.7976125
Inverse variance weighted	23	0.0115205	0.0389185	0.7672186
Simple mode	23	-0.0691726	0.1018303	0.5040369
Weighted mode	23	-0.1014798	0.0709482	0.1666706

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.21793	21	0.6978138
Inverse variance weighted	22.95257	22	0.4044118

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0131952	0.0055101	0.0260399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006983	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8