Two sample MR report

Telomere_length against IDP T1 FAST ROIs R planum temporale

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1476823	0.1161862	0.2175990
Weighted median	23	-0.1033206	0.0530734	0.0515646
Inverse variance weighted	23	-0.0592289	0.0450848	0.1889403
Simple mode	23	-0.0201231	0.0863486	0.8178809
Weighted mode	23	-0.0996077	0.0582694	0.1014406

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.83054	21	0.0954465
Inverse variance weighted	30.80230	22	0.1002324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054318	0.0065673	0.417479

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010066	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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