Two sample MR report

Telomere_length against IDP T1 FAST ROIs R planum polare

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1227353	0.1017045	0.2409344
Weighted median	23	-0.0996350	0.0557437	0.0738767
Inverse variance weighted	23	-0.0656142	0.0391808	0.0940028
Simple mode	23	-0.0815845	0.0867358	0.3571192
Weighted mode	23	-0.1027791	0.0602337	0.1020239

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.85779	21	0.3516073
Inverse variance weighted	23.26305	22	0.3870059

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035077	0.0057487	0.5482917

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007948	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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