Two sample MR report

Telomere_length against IDP T1 FAST ROIs R parahipp gyrus post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0112837	0.1183717	0.9249611
Weighted median	23	0.0927005	0.0561405	0.0986928
Inverse variance weighted	23	0.1104988	0.0465280	0.0175542
Simple mode	23	0.0812533	0.0905950	0.3794906
Weighted mode	23	0.0670020	0.0645144	0.3102903

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.96349	21	0.0742677
Inverse variance weighted	32.80555	22	0.0646620

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074785	0.0066908	0.2763075

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012489	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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