Two sample MR report

Telomere_length against IDP T1 FAST ROIs R parahipp gyrus ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0305887	0.1111720	0.7858922
Weighted median	23	0.0135029	0.0575925	0.8146307
Inverse variance weighted	23	0.0511337	0.0424942	0.2288559
Simple mode	23	0.0572221	0.1062895	0.5957334
Weighted mode	23	0.0153147	0.0630736	0.8104040

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.31126	21	0.1607864
Inverse variance weighted	27.36369	22	0.1977377

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012616	0.0062838	0.8428059

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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