Two sample MR report

Telomere_length against IDP T1 FAST ROIs R paracing gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0446485	0.1357857	0.7455516
Weighted median	23	0.0007317	0.0597523	0.9902303
Inverse variance weighted	23	-0.0144766	0.0521281	0.7812335
Simple mode	23	0.1409990	0.1317931	0.2962841
Weighted mode	23	-0.0461921	0.0765224	0.5522555

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.74408	21	0.0060301
Inverse variance weighted	41.17826	22	0.0078476

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036308	0.0076751	0.6410502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012521	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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