Two sample MR report

Telomere_length against IDP T1 FAST ROIs R pallidum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0866993	0.1004549	0.3978507
Weighted median	23	0.0265673	0.0582683	0.6484271
Inverse variance weighted	23	0.0199603	0.0388336	0.6072550
Simple mode	23	0.0120916	0.1127012	0.9155322
Weighted mode	23	0.0120916	0.0920588	0.8966951

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.29932	21	0.3824408
Inverse variance weighted	22.85253	22	0.4100967

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040983	0.0056781	0.4783875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007008	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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