Two sample MR report

Telomere_length against IDP T1 FAST ROIs R occ fusif gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0542813	0.0974847	0.5835375
Weighted median	23	0.0452424	0.0559912	0.4190749
Inverse variance weighted	23	0.0468674	0.0381027	0.2186856
Simple mode	23	0.0760189	0.0900110	0.4074523
Weighted mode	23	0.0340402	0.0677902	0.6205574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.58339	21	0.6118462
Inverse variance weighted	19.85409	22	0.5921660

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062114	0.0055101	0.2723497

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006475	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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