Two sample MR report

Telomere_length against IDP T1 FAST ROIs R mid front gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1499669	0.1472150	0.3199420
Weighted median	23	-0.0326463	0.0630332	0.6045125
Inverse variance weighted	23	-0.0698440	0.0566834	0.2178829
Simple mode	23	-0.0140167	0.1180474	0.9065604
Weighted mode	23	-0.0411678	0.0808699	0.6157771

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.89383	21	0.0007109
Inverse variance weighted	48.69122	22	0.0008786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049203	0.0083212	0.5606346

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015771	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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