Two sample MR report

Telomere_length against IDP T1 FAST ROIs R lingual gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0105228	0.0974853	0.9150660
Weighted median	23	0.0454835	0.0522636	0.3841526
Inverse variance weighted	23	0.0558060	0.0381027	0.1430243
Simple mode	23	-0.0257015	0.0814123	0.7552087
Weighted mode	23	0.0530177	0.0679035	0.4432527

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.17385	21	0.5102743
Inverse variance weighted	20.72027	22	0.5380788

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040731	0.0055102	0.4679687

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006928	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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