Two sample MR report

Telomere_length against IDP T1 FAST ROIs R hippocampus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1590576	0.1471081	0.2918560
Weighted median	23	0.0036223	0.0623251	0.9536534
Inverse variance weighted	23	0.0498206	0.0570402	0.3824283
Simple mode	23	0.0425625	0.1217255	0.7299189
Weighted mode	23	-0.0385841	0.0997251	0.7025443

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.82350	21	0.0007267
Inverse variance weighted	49.30563	22	0.0007273

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067081	0.0083151	0.4288605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015458	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8