Two sample MR report

Telomere_length against IDP T1 FAST ROIs R heschl gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2518345	0.0974833	0.0173357
Weighted median	23	-0.1245112	0.0532588	0.0193949
Inverse variance weighted	23	-0.0622733	0.0381023	0.1021808
Simple mode	23	-0.1048712	0.0995408	0.3035236
Weighted mode	23	-0.1466929	0.0676842	0.0413083

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.55780	21	0.8878342
Inverse variance weighted	18.02091	22	0.7047479

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0116408	0.0055101	0.0467813

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000627	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8