Two sample MR report

Telomere_length against IDP T1 FAST ROIs R frontal pole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0023302	0.1398008	0.9868586
Weighted median	23	-0.0684624	0.0653987	0.2951697
Inverse variance weighted	23	-0.0454672	0.0535288	0.3956601
Simple mode	23	-0.1000949	0.1296058	0.4481528
Weighted mode	23	-0.1338078	0.0783053	0.1015608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.19033	21	0.0029722
Inverse variance weighted	43.42146	22	0.0041861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002649	0.0079021	0.740779

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013589	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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