Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cing gyrus post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0806138	0.1182788	0.5029667
Weighted median	23	0.0487464	0.0576886	0.3981156
Inverse variance weighted	23	0.0181600	0.0455199	0.6899324
Simple mode	23	-0.0131031	0.1029352	0.8998635
Weighted mode	23	0.0115473	0.0709017	0.8721125

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.91467	21	0.0750899
Inverse variance weighted	31.39911	22	0.0882332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038352	0.0066855	0.572294

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009584	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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