Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cing gyrus ant

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0845715 0.1022904 0.4176585
Weighted median 23 -0.0356347 0.0575848 0.5360339
Inverse variance weighted 23 -0.0620089 0.0391152 0.1129008
Simple mode 23 0.0010781 0.1015141 0.9916219
Weighted mode 23 0.0092004 0.0771355 0.9061393

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.12198 21 0.3375092
Inverse variance weighted 23.18521 22 0.3913353

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0013855 0.0057818 0.8129352

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007829 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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