Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum crus II

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0637825	0.1592621	0.6928428
Weighted median	23	0.0177280	0.0569717	0.7556701
Inverse variance weighted	23	-0.0556625	0.0608224	0.3601047
Simple mode	23	-0.0576429	0.1008582	0.5734376
Weighted mode	23	-0.0214711	0.0626296	0.7349830

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.05153	21	4.96e-05
Inverse variance weighted	56.05972	22	8.38e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004986	0.0090019	0.9563505

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017632	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8