Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum crus I

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1218833	0.0974847	0.2249500
Weighted median	23	0.0631745	0.0558639	0.2581123
Inverse variance weighted	23	0.0119072	0.0381026	0.7546583
Simple mode	23	0.0436966	0.0973656	0.6579735
Weighted mode	23	0.0668885	0.0671909	0.3303176

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.08074	21	0.6438893
Inverse variance weighted	19.58292	22	0.6091111

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067535	0.0055102	0.2339043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005964	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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